Deciphering the Chemical Properties of 79-24-3: A Comprehensive Analysis


Compound 79-24-3, also known as 2,5-Dimethoxy-4-methylamphetamine (DOM), belongs to the class of substituted amphetamines and has been studied for its psychoactive effects. Investigating its chemical properties is crucial for understanding its pharmacological actions and potential therapeutic applications.

Chemical Identity:

  • Chemical Name: 2,5-Dimethoxy-4-methylamphetamine (DOM)
  • Molecular Formula: C12H19NO2
  • Chemical Structure:
  • Synonyms: STP, Serenity, Essence

Physical Properties:

  • Appearance: 79-24-3 typically presents as a white to off-white crystalline powder or solid.
  • Melting Point: The melting point of DOM falls within the range of approximately 125-130°C.
  • Boiling Point: DOM decomposes upon heating, and a precise boiling point is challenging to determine.
  • Solubility: It is sparingly soluble in water but dissolves readily in organic solvents such as ethanol and methanol.

Chemical Properties:

  • Stability: DOM is relatively stable under ambient conditions but may undergo degradation upon exposure to heat, light, or acidic or basic environments.
  • Reactivity: It can undergo various chemical transformations, including oxidation, reduction, and formation of amine derivatives.
  • Pharmacophore: DOM contains a methoxyphenyl ring and an amine moiety, contributing to its pharmacological properties and psychoactive effects.

Pharmacological Effects:

  • Psychoactivity: DOM exhibits hallucinogenic and psychedelic effects, altering perception, mood, and cognition.
  • Serotonin Receptor Agonism: It acts primarily as a partial agonist at serotonin 5-HT2A receptors, leading to its hallucinogenic effects.
  • Duration of Action: The effects of DOM can last up to 12-24 hours, with a slow onset and gradual offset of action.

Toxicological Considerations:

  • Acute Toxicity: High doses of DOM can lead to acute toxicity, manifested by symptoms such as hallucinations, agitation, and cardiovascular complications.
  • Long-Term Effects: Chronic use of DOM may result in psychological dependence, flashbacks, and persistent perceptual disturbances.

Therapeutic Potential:

  • Psychedelic Therapy: Despite its recreational use, DOM and related compounds have been investigated for their potential therapeutic applications in psychedelic-assisted psychotherapy.


79-24-3, or DOM, exhibits complex chemical and pharmacological properties, contributing to its psychoactive effects and potential therapeutic applications. Further research into its pharmacology, toxicology, and therapeutic potential is necessary to harness its benefits while mitigating potential risks associated with its use.

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